CXCR4/SDF1 interaction inhibits the primordial to primary follicle transition in the neonatal mouse ovary
نویسندگان
چکیده
منابع مشابه
The primordial to primary follicle transition.
The mechanisms that regulate the gradual exit of ovarian follicles from the non-growing, primordial pool are very poorly understood. A better understanding of the signals that initiate follicular growth in mammals, and of the conditions necessary for sustained growth of early preantral follicles in vitro, could have practical implications for contraception, alleviation of infertility, and regul...
متن کاملLow expression of SEMA6C accelerates the primordial follicle activation in the neonatal mouse ovary
The primordial follicle assembly, activation and the subsequent development are critical processes for female reproduction. A limited number of primordial follicles are activated to enter the growing follicle pool each wave, and the primordial follicle pool progressively diminishes over a woman's life-time. The number of remaining primordial follicles represents the ovarian reserve. Identificat...
متن کاملSuppression of Notch signaling in the neonatal mouse ovary decreases primordial follicle formation.
Notch signaling directs cell fate during embryogenesis by influencing cell proliferation, differentiation, and apoptosis. Notch genes are expressed in the adult mouse ovary, and roles for Notch in regulating folliculogenesis are beginning to emerge from mouse genetic models. We investigated how Notch signaling might influence the formation of primordial follicles. Follicle assembly takes place ...
متن کاملAnti-Müllerian Hormone Inhibits Initiation of Primordial Follicle Growth in the Mouse Ovary.
Recruitment of primordial follicles is essential for female fertility; however, the exact mechanisms regulating this process are largely unknown. Earlier studies using anti-Müllerian hormone (AMH)-deficient mice suggested that AMH is involved in the regulation of primordial follicle recruitment. We tested this hypothesis in a neonatal ovary culture system, in which ovaries from 2-d-old C57Bl/6J...
متن کاملMorphometric characteristics of the primordial to primary follicle transition in the human ovary in relation to age.
BACKGROUND The growth pattern of the smallest ovarian follicles in humans is still incompletely documented. Using follicle hemispheres in thick histological sections, morphometric changes of primordial to primary follicles and possible age-related effects were evaluated. METHODS In ovarian sections from 25 females aged 4-39 years a total of 1122 primordial, transitory or primary follicles wer...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Biology
سال: 2006
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2006.02.012